研究成果 |
探究了溶酶体TMEM175钾离子通道调控帕金森病的分子机制，解析了Melatonin对外周组织生物钟节律和代谢的调节机制，以第一作者和通讯作者在Nature，Genetics in medicine，Journal of Pineal Research等杂志累计发表SCI论文30余篇，被引用1200余次；主持国家自然基金青年基金、国家农业重大科技项目子课题、吉林省科技发展计划和西藏自治区重点研发项目各1项。 课题组工作聚焦溶酶体生物学功能调控神经系罕见病和退行性疾病的分子遗传机制。 代表性论文：
Liu W, Fan X, Jian B, Wen D, Wang H, Liu Z*, Li B. The signaling pathway of hypoxia inducible factor in regulating gut homeostasis. Front Microbiol. 2023 Oct 27;14:1289102. doi: 10.3389/fmicb.2023.1289102. (IF: 5.2) Bayat A#, Liu Z#, Luo S#, Fenger CD, Hojte AF, Isidor B, Cogne B, Larson A, Zanus C, Flavio F, Keren B, Musante L, Gourfinkel-An I, Perrine C, Demily C, Lesca G, Liao W, Ren D. A new neurodevelopmental disorder linked to heterozygous variants in UNC79. Genetics in Medicine. 2023 Sep;25(9):100894. doi: 10.1016/j.gim.2023.100894 (IF: 8.864) Niu Y, Liu W, Fan X, Wen D, Wu D, Wang H, Liu Z*, Li B. Beyond cellulose: pharmaceutical potential for bioactive plant polysaccharides in treating disease and gut dysbiosis. Front Microbiol. 2023 May 24;14:1183130. doi: 10.3389/fmicb.2023.1183130. (IF: 5.2) Tang T, Jian B, Liu Z*. Transmembrane Protein 175, a Lysosomal Ion Channel Related to Parkinson’s Disease. Biomolecules. 2023; 13(5):802. https://doi.org/10.3390/biom13050802 (IF: 6.064) Wie, J., Liu, Z., Song, H., Tropea, T.F., Yang, L., Wang, H., Liang, Y., Cang, C., Aranda, K., Lohmann, J., Yang, J., Lu, B., Chen-Plotkin, A.S., Luk, K.C. and Ren, D. A potassium channel in lysosomes regulates Parkinson’s pathology. Nature. (2021): 1-7. https://doi.org/10.1038/s41586- (IF: 69.504) Liu Z., Gan L., Zhang T., Ren Q., Sun C. Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice. Journal of Pineal Research. 2018 Jan;64(1). doi: 10.1111/jpi.12455 (IF: 15.221) Liu Z., Gan L., Xu Y., Luo D., Ren Q., Wu S., Sun C. Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue. Journal of Pineal Research. 2017 Aug;63(1). doi: 10.1111/jpi.12414. (IF: 15.221) Liu Z., Gan L., Luo D., Sun C. Melatonin promotes circadian rhythm-induced proliferation through interaction of Clock/HDAC3/c-Myc in mice adipose tissue. Journal of Pineal Research. 2017 May;62(4). doi: 10.1111/jpi.12383. (IF: 15.221) Gan L., Liu Z., Sun C. Obesity linking to hepatocellular carcinoma: A global view. Biochimica et Biophysica Acta -Reviews on Cancer. 2018 Apr; 1869(2): 97-102. doi: 10.1016/j.bbcan. 2017.12.006. (IF: 7.365) Liu Z., Gan L., Wu, T., Feng, F., Luo, D., Liu, S., Sun, C. Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose. Cell Death and Disease. 2016 Nov 24;7(11): e2487. doi: 10.1038/cddis.2016.388. |
